Dr. Amarendranath Choudhury
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dr._a choudhury -scopus.pdf | |
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aus_conference_book_scanned.pdf | |
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abstract-ian2016.pdf | |
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dr._amarendranath_choudhury_-_google_scholar_citations.pdf | |
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PUBLICATION HIGHLIGHTS
Sl. no. |
Article title |
Journal |
Impact factor |
1. |
Neuroprotective Potential of Silymarin against CNS Disorders: Insight into the Pathways and Molecular Mechanisms of Action. |
CNS Neuroscience & Therapeutics |
4.449 |
2. |
Cholesterol- a putative endogenous contributor towards Parkinson’s disease. |
Neurochemistry International |
3.334 |
3. |
Cholesterol in pancreatic β-cell death and dysfunction: underlying mechanisms and pathological implications. |
Pancreas Journal |
3.09 |
4. |
L-DOPA treatment in MPTP-mouse model of Parkinson’s disease potentiates homocysteine accumulation in substantia nigra. |
Neuroscience Letters |
2.23 |
5. |
Hypercholesterolemia causes psycho-motor abnormalities in mice at the expense of altered cortico-striatal biogenic amine neurotransmitters: relevance to Parkinson’s disease. |
Neurochemistry international |
3.334 |
6. |
Cholesterol contributes to dopamine-neuronal loss in MPTP mouse model of Parkinson’s disease: Involvement of mitochondrial dysfunction and oxidative stress. |
PlosOne |
3.43 |
7. |
Artificial Intelligence in Biological Data |
J Inform Tech Softw Eng |
0.5 |
8. |
Cognitive and Psychological Anomalies in Parkinson’s Disease: An Insight into Non-Motor Characteristic Features. |
Neuropsychiatry |
4.77 |
9. |
Retromer dysfunction causes synucleinopathy in Parkinson’s disease: Pharmacological chaperons as a therapeutic intervention |
Neurochemistry International |
Commu. |
10. |
Neuroprotective effect of Ayurvedic preparations and natural products on Parkinson’s disease. In: Brahmachari (Ed.): Neuroprotective Natural Products, Clinical Aspects and Mode of Action. |
Wiley-VCH Publication. Berlin. Germany. |
Book |
11. |
A transient mice model of Parkinsonism: An experimental evidence of psycho-motor behavioral recovery. |
Neuroscimistry International |
Commu. |
12. |
Neuroenhancing Phytochemicals in Health and Disease: An insight into Ayurvedic Phytotherapy. |
OmniScriptum GmbH & Co. KG. |
Book |
13. |
Efficacy of Morin as a Potential Therapeutic Phytocomponent: Insights into the Mechanism of Action. |
Int J Med Res Health Sci. |
0.75 |
14. |
CRISPR/Cas9 genome editing system in the diagnosis and treatment of cancer. |
Journal of RNAi and Gene Silencing |
3.25 |
15. |
Effect and Disease Indicative Role of Inflammation in Neurodegenerative pathology: A Mechanistic Cross-talk of Promise and Dilemma. |
Neuropsychiatry |
4.77 |
16. |
Neurochemicals, Behaviours and Psychiatric Perspectives of Neurological Diseases. |
Neuropsychiatry |
4.77 |
17 |
Understanding the Role of Resveratrol in Major Neurological and Lifestyle Diseases: An Insight into Molecular Mechanisms and Druggability. |
Pharmaceutical BioProcessing |
0.47 |
FRONT PAGE OF PUBLISHED ARTICLES
TOPIC HIGHLIGHTS OF PUBLISHED ARTICLES
PlosOne_2017Hypercholesterolemia is a known contributor to the pathogenesis of Alzheimer's disease while its role in the occurrence of Parkinson's disease (PD) is only conjecture and far from conclusive. Altered antioxidant homeostasis and mitochondrial functions are the key mechanisms in loss of dopaminergic neurons in the substantia nigra (SN) region of the midbrain in PD. Hypercholesterolemia is reported to cause oxidative stress and mitochondrial dysfunctions in the cortex and hippocampus regions of the brain in rodents. However, the impact of
hypercholesterolemia on the midbrain dopaminergic neurons in animal models of PD remains elusive. We tested the hypothesis that hypercholesterolemia in MPTP model of PD would potentiate dopaminergic neuron loss in SN by disrupting mitochondrial functions and antioxidant homeostasis. It is evident from the present study that hypercholesterolemia in naïve animals caused dopamine neuronal loss in SN with subsequent reduction in striatal dopamine levels producing motor impairment. Moreover, in the MPTP model of PD, hypercholesterolemia exacerbated MPTP-induced reduction of striatal dopamine as well as dopaminergic neurons in SN with motor behavioral depreciation. Activity of mitochondrial complexes, mainly complex-I and III, was impaired severely in the nigrostriatal pathway of hypercholesterolemic animals treated with MPTP. Hypercholesterolemia caused oxidative stress in the nigrostriatal pathway with increased generation of hydroxyl radicals and enhanced activity of antioxidant enzymes, which were further aggravated in the hypercholesterolemic mice with Parkinsonism. In conclusion, our findings provide evidence of increased vulnerability of the midbrain dopaminergic neurons in PD with hypercholesterolemia.
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Neurochemistry Int._2017The symptoms of Parkinson's disease (PD) include motor behavioral abnormalities, which appear as a result of the extensive loss of the striatal biogenic amine, dopamine. Various endogenous molecules, including cholesterol, have been put forward as putative contributors in the pathogenesis of PD. Earlier reports have provided a strong link between the elevated level of plasma cholesterol (hypercholesterolemia) and onset of PD. However, the role of hypercholesterolemia on brain functions in terms of neurotransmitter metabolism and associated behavioral manifestations remain elusive.
We tested in Swiss albino mice whether hypercholesterolemia induced by high-cholesterol diet would affect dopamine and serotonin metabolism in discrete brain regions that would precipitate in psychomotor behavioral manifestations. High-cholesterol diet for 12 weeks caused a significant increase in blood total cholesterol level, which validated the model as hypercholesterolemic. Tests for akinesia, catalepsy, swimming ability and gait pattern (increased stride length) have revealed that hypercholesterolemic mice develop motor behavioral abnormalities, which are similar to the behavioral phenotypes of PD. Moreover, hypercholesterolemia caused depressive-like behavior in mice, as indicated by the increased immobility time in the forced swim test. We found a significant depletion of dopamine in striatum and serotonin in cortex of hypercholesterolemic mice. The significant decrease in tyrosine hydroxylase immunoreactivity in striatum supports the observed depleted level dopamine in striatum, which is relevant to the pathophysiology of PD. In conclusion, hypercholesterolemia-induced depleted levels of cortical and striatal biogenic amines reported hereby are similar to the PD pathology, which might be associated with the observed psychomotor behavioral abnormalities.
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IJTSE_2017Artificial Intelligence (AI) or Machine learning in present era, serves as the primary choice for data mining and big data analysis. With effective learning and adaptation model, it provides solutions to several engineering applications. These include techniques such as Artificial Neural Network modelling, Reasoning based decision algorithms, Simulation models, DNA computing and Quantum computing among several others. With the application of AI in Biomedical research, the fuzziness and randomness in handling such type of data has significantly reduced. Rapid technological
advancements have helped AI techniques evolve in manner which promotes handling such fuzzy data effectively and much more conveniently. The review presents a comprehensive view of machine learning and AI computing models, advanced data analytics and optimisation approaches used in Bioengineering such as Drug Designing and Analysis, Medical imaging, biologically inspired learning and adaption for analytics, etc.
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OTHER PUBLISHED ARTICLES
rnai_and_genomics_2017.pdf | |
File Size: | 480 kb |
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choudhury_et_al_2017.pdf | |
File Size: | 551 kb |
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neuroscience_letter_2016.pdf | |
File Size: | 1150 kb |
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neurochemistry_international_2015.pdf | |
File Size: | 833 kb |
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cns_neuroscience___therapeutics_2013.pdf | |
File Size: | 196 kb |
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pancreas_journal_2016.pdf | |
File Size: | 413 kb |
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book_chapter.pdf | |
File Size: | 1085 kb |
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choudhury_et_al._2017_neuropsychiatry | |
File Size: | 223 kb |
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12._choudhury_et_al_2018_neuropsychiatry.pdf | |
File Size: | 65 kb |
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neuroscience_chronicles_2020.pdf | |
File Size: | 345 kb |
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